Human Colon Cancer Profiles Show Differential MicroRNA Expression Depending on Mismatch Repair Status and are Characteristic of Undifferentiated Proliferative States Book PDF, ePub eBook

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Book Descriptions:
Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate gene expression. Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression. Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states.

Human Colon Cancer Profiles Show Differential MicroRNA Expression Depending on Mismatch Repair Status and are Characteristic of Undifferentiated Proliferative States by Applied Research Press

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